Purpose: This study has presented the local model of knowledge management in research-oriented organizations and the need for its implementation in such organizations. Methodology: The present study is an exploratory mix in terms of applied purpose and data collection, and a cross-sectional survey in terms of nature and type. In the qualitative section, 31 ACECR experts were selected, and in the quantitative section, 100 people were selected as the sample of ACECR managers and elites. Interview data collection tool, questionnaire, and data collected were analyzed by SPSS software. Content analysis and confirmatory factor analysis using software (EQS) were used to analyze the data. Findings: Finally, data analysis showed that this indigenous model has eight key dimensions with 55 vital components and infrastructural dimensions of culture, structure and technology. The relationship between dimensions, components and infrastructures is designed and presented in the form of a conceptual model and a matrix. Conclusion: Most research-based organizations in Iran do not have a coherent model in the field of knowledge management or have several problems in its implementation. Providing an indigenous model appropriate to the culture and structure of Iran can lead these organizations to develop and achieve a competitive advantage through the systematic management of intellectual assets. Therefore, by creating the necessary infrastructure in the field of information technology, culture and modification of processes and organizational structure, knowledge management can be implemented in research-based organizations.